Principal Scientist – Cardiovascular Gene and RNA Therapeutics

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The Mass General Brigham Gene & Cell Therapy Institute (GCTI) is a system-wide institute dedicated to advancing innovative gene, cell, and RNA-based therapies from discovery to clinical application. We are seeking an accomplished scientist to lead translational research programs focused on cardiovascular gene and RNA therapeutics, with particular emphasis on cardiac fibrosis, myocardial remodeling, heart failure, and therapeutic development.

The successful candidate will develop novel therapeutic strategies, oversee preclinical research, and collaborate with multidisciplinary teams to advance promising candidates toward clinical translation. Principal Duties and Responsibilities

• Lead research programs focused on cardiovascular gene and RNA therapeutics, including antifibrotic and cardiac repair strategies.
• Develop and evaluate AAV-based, mRNA, circular RNA, and other nucleic acid therapeutics.
• Investigate molecular mechanisms underlying cardiac fibrosis, myocardial remodeling, and heart failure.
• Design and execute in vitro and in vivo studies to evaluate therapeutic efficacy, mechanisms of action, and safety.
• Develop and optimize therapeutic constructs, delivery approaches, and molecular assays.
• Collaborate with GCTI's CMC, regulatory, and translational teams to advance programs toward IND-enabling studies.
• Contribute to scientific publications, grant applications, intellectual property development, and external collaborations.
• Supervise and mentor research personnel while ensuring scientific rigor and reproducibility.

Qualifications Required Qualifications PhD in Cardiovascular Biology, Molecular Biology, Biomedical Sciences, Genetics, or a related discipline. Minimum of 3 years of relevant postdoctoral or industry research experience. Strong expertise in cardiovascular biology, molecular mechanisms of disease, and therapeutic development.

Experience with molecular biology techniques, gene expression analysis, and preclinical disease models. Demonstrated ability to independently design experiments, analyze data, and lead collaborative research projects. Excellent scientific communication, organizational, and leadership skills.

Expertise in cardiac fibrosis, myocardial remodeling, and heart failure. Experience with CCN5 or related antifibrotic therapeutic pathways. Experience developing AAV-based gene therapies or RNA therapeutics.

Familiarity with mRNA, circular RNA, and lipid nanoparticle delivery technologies. Experience in cardiovascular animal models and translational research. Knowledge of preclinical development, regulatory requirements, and IND-enabling studies.

Strong publication record, grant-writing experience, and demonstrated ability to mentor scientists. Expected Outcomes The successful candidate will advance cardiovascular gene and RNA therapeutic programs, generate preclinical proof-of-concept data, establish translational development strategies, and contribute to GCTI's mission of bringing innovative genetic medicines toward clinical application. Additional Job Details (if applicable) Working Conditions This is a part-time, 20-hour/week position The salary range for this position is $45,000.00 to $47,500.00.

At Mass General Brigham, we believe in recognizing and rewarding the unique value each team member brings to our organization. Our approach to determining base pay is comprehensive, and any offer extended will take into account your skills, relevant experience, education, certifications, and other essential factors. The base pay information provided offers an estimate based on the job qualifications; however, it does not encompass all elements contributing to your total compensation package.

In addition to competitive base pay, we offer comprehensive benefits and career advancement opportunities, along with recognition programs designed to celebrate your contributions and support your professional growth. We invite candidates to apply, and our Talent Acquisition team will provide an overview of their potential compensation and benefits package. Remote Type Hybrid Work Location 149 Thirteenth Street Building 149 Scheduled Weekly Hours 20 Employee Type Regular Work Shift Day EEO Statement: 0100 Mass General Brigham Incorporated is an Equal Opportunity Employer.

All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.

To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran’s Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership “looks like” by specifying which behaviors are most critical for successful performance at each job level.

The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.